Taconic Biosciences Launches First and Only Super Immunodeficient Mouse Models Lacking Residual Murine Fc Gamma Receptors, for Improved Antibody Therapy Assessment

FcResolv™ NOG Models Provide Greater Clarity and More Translatable Data

RENSSELAER, N.Y., Oct. 24, 2022 (GLOBE NEWSWIRE) — Taconic Biosciences, a global leader in providing drug discovery animal model solutions, has launched the FcResolv™ NOG portfolio, the first and only super immunodeficient mouse models lacking residual murine Fc gamma receptors (FcγRs) known to confound results in antibody-based therapy studies.

Murine FcγRs can cause false positives or false negatives, leading to incorrect conclusions and derail drug discovery. FcResolv NOG models knock out these receptors for greater clarity in antibody-based drug studies, affording investigators greater confidence and more translatable data with fewer studies and fewer animals. With applicability in oncology, immuno-oncology, and autoimmune disease, FcResolv NOG models are suitable for engrafting a wide range of human cells and tissues, including simultaneous human tumor engraftment and immune system humanization.

“Antibody-based therapies represent one of the fastest-growing classes of drugs, creating a pressing need for better preclinical tools to assess therapeutics such as monoclonal antibodies, antibody-drug conjugates, and bispecific antibodies,” said Dr. Michael Seiler, vice president of commercial products at Taconic. “Taconic’s FcResolv NOG portfolio enables researchers to evaluate drug candidates like these on their own merits, free of interference from residual murine Fc gamma receptor activity.”

FcResolv NOG models eliminate the false negatives that occur when an antibody-based therapeutic’s Fc domain interacts with murine FcγRs as well as the false positives that result when FcγRs trigger residual murine immune activity. They also eliminate costly deconvolution steps otherwise needed to distinguish true drug efficacy from off-target effects mediated through the mouse immune system. With more reliable answers, researchers can target their drug discovery investments more strategically and effectively.

The FcResolv NOG model portfolio is based on the super immunodeficient CIEA NOG mouse®. The portfolio currently includes two models:

  • FcResolv NOG, for tumor xenografts using cell lines or patient-derived tumors, engraftment of other normal or pathological human cells and tissues, and immune system humanization studies
  • FcResolv hIL-15 NOG, which supports engraftment of human NK cells and is suitable for efficacy studies on antibody-based therapeutics with an antibody-dependent cellular cytotoxicity (ADCC) mechanism of action

To learn more about the FcResolv NOG portfolio, visit www.Taconic.com/fcresolv. Or call 1-888-TACONIC (888-822-6642) in the US, +45 70 23 04 05 in Europe, or email info@taconic.com.

About Taconic Biosciences, Inc.

Taconic Biosciences is a fully licensed, global leader in genetically engineered rodent models and services. Founded in 1952, Taconic provides the best animal solutions so that customers can acquire, custom-generate, breed, precondition, test, and distribute valuable research models worldwide. Specialists in genetically engineered mouse and rat models, microbiome, immuno-oncology mouse models, and integrated model design and breeding services, Taconic operates service laboratories and breeding facilities in the U.S. and Europe, maintains distributor relationships in Asia and has global shipping capabilities to provide animal models almost anywhere in the world.

Media Contact:

Louise Baskin, Senior Director New Product Pipeline

303-432-2495

Louise.Baskin@taconic.com

GlobeNewswire Distribution ID 8670208

Taconic Biosciences lance le premier et le seul modèle de souris super immunodéficientes dépourvus de récepteurs Fc Gamma murins résiduels, pour une évaluation améliorée de la thérapie par anticorps

Les modèles FcResolv™ NOG offrent une plus grande clarté et des données plus traduisibles

RENSSELAER, New York, 24 oct. 2022 (GLOBE NEWSWIRE) — Taconic Biosciences, un leader mondial dans la fourniture de solutions de modèles animaux pour la découverte de médicaments, a lancé le portefeuille FcResolv™ NOG, les premiers et seuls modèles de souris super immunodéficientes dépourvus de récepteurs Fc Gamma murins résiduels (FcyRs) connus pour fausser les résultats dans les études thérapeutiques à base d’anticorps.

Les FcyRs murins peuvent provoquer de faux positifs ou de faux négatifs, ce qui conduit à des conclusions erronées et fait dérailler la découverte de médicaments. Les modèles FcResolv NOG éliminent ces récepteurs pour une plus grande clarté dans les études médicamenteuses à base d’anticorps, offrant aux chercheurs une plus grande confiance et des données plus traduisibles avec moins d’études et moins d’animaux. Avec une applicabilité en oncologie, en immuno-oncologie et en maladie auto-immune, les modèles FcResolv NOG sont adaptés à la greffe d’un large éventail de cellules et tissus humains, y compris la greffe de tumeurs humaines simultanée et l’humanisation du système immunitaire.

« Les thérapies à base d’anticorps représentent l’une des classes de médicaments à la croissance la plus rapide, créant un besoin urgent de meilleurs outils précliniques pour évaluer des traitements tels que les anticorps monoclonaux, les conjugués anticorps-médicaments et les anticorps bispécifiques », a déclaré le Dr Michael Seiler, vice-président des produits commerciaux chez Taconic. « Le portefeuille de récepteurs FcResolv NOG de Taconic permet aux chercheurs d’évaluer des médicaments candidats tels que ceux-ci selon leurs propres mérites, sans interférence de l’activité résiduelle du récepteur Fc Gamma murin. »

Les modèles FcResolv NOG éliminent les faux négatifs qui se produisent lorsqu’un domaine Fc thérapeutique à base d’anticorps interagit avec les FcyRs murins, ainsi que les faux positifs qui en résultent lorsque les FcyRs déclenchent une activité immunitaire murine résiduelle. Ils éliminent également les étapes de déconvolution coûteuses nécessaires pour distinguer une véritable efficacité médicamenteuse des effets hors cible induits par le système immunitaire de la souris. Grâce à des réponses plus fiables, les chercheurs peuvent cibler leurs investissements dans la découverte de médicaments de manière plus stratégique et plus efficace.

Le portefeuille de modèles NOG FcResolv est basé sur la souris® NOG CIEA super immunodéficiente. Le portefeuille comprend actuellement deux modèles :

  • FcResolv NOG, pour les xérogreffes tumorales utilisant des lignées cellulaires ou des tumeurs dérivées des patients, la greffe d’autres cellules et tissus humains normaux ou pathologiques, et les études d’humanisation du système immunitaire
  • FcResolv hIL-15 NOG, qui supporte la greffe des cellules NK humaines et convient pour des études d’efficacité sur les thérapies à base d’anticorps avec un mécanisme d’action de cytotoxicité cellulaire dépendant des anticorps (ADCC)

Pour en savoir plus sur le portefeuille de FcResolv NOG, rendez-vous sur www.Taconic.com/fcresolv. Vous pouvez également appeler le 1-888-TACONIC (888-822-6642) aux États-Unis, le +45 70 23 04 05 en Europe, ou envoyer un e-mail à l’adresse info@taconic.com.

À propos de Taconic Biosciences, Inc.

Taconic Biosciences est un leader mondial pleinement agréé dans les modèles et les services de rongeurs génétiquement modifiés. Fondée en 1952, Taconic offre les meilleures solutions animales afin que les clients puissent acquérir, générer d’une manière personnalisée, élever, pré-conditionner, tester et distribuer des modèles de recherche précieux dans le monde entier. Spécialiste des modèles de souris et de rats génétiquement modifiés, du microbiome, des modèles de souris pour l’immuno-oncologie et des services de conception de modèles intégrés et d’élevage, Taconic exploite des laboratoires de services et des établissements d’élevage aux États-Unis et en Europe, entretient des relations de distribution en Asie et dispose de capacités d’expédition mondiales pour fournir des modèles animaux presque partout dans le monde.

Contact auprès des médias :

Louise Baskin, directrice principale du nouveau Pipeline de produits

303-432-2495

Louise.Baskin@taconic.com

GlobeNewswire Distribution ID 8670426


Taconic Biosciences Lança Primeiro e Único Modelo de Camundongo Super Imunodeficiente Sem Receptores Gama Fc Murino Residuais, para Avaliação de Terapia de Anticorpo Aprimorada

Modelos FcResolv™ NOG proporcionam dados mais claros e mais traduzíveis

RENSSELAER, NY, Oct. 24, 2022 (GLOBE NEWSWIRE) — A Taconic Biosciences, líder global no fornecimento de soluções de modelo animal para descoberta de medicamentos, lançou o portfólio FcResolv™ NOG, o primeiro e único modelo de camundongo superimunodeficiente sem receptores Fc gama murinos residuais (FcγRs) conhecidos por confundir os resultados nos estudos de terapia com base em anticorpos.

Os FcγRs murinos podem causar falsos positivos ou falsos negativos, levando a conclusões incorretas e afetar a descoberta de medicamentos. Os modelos FcResolv NOG eliminam esses receptores para maior clareza nos estudos de medicamentos com base em anticorpos, proporcionando aos investigadores maior confiança e dados mais traduzíveis, com menos estudos e menos animais. Com aplicabilidade em oncologia, imuno-oncologia e doença autoimune, os modelos FcResolv NOG são adequados para enxertos de uma ampla gama de células e tecidos humanos, incluindo enxerto simultâneo de tumor humano e humanização do sistema imunológico.

“As terapias com base em anticorpos são uma das classes de medicamentos de crescimento mais rápido, criando uma necessidade urgente de melhores ferramentas pré-clínicas para a avaliação terapêutica, como de anticorpos monoclonais, conjugados anticorpo-droga e anticorpos biespecíficos”, disse o Dr. Michael Seiler, vice-presidente de produtos comerciais da Taconic. “O portfólio FcResolv NOG da Taconic permite que pesquisadores avaliem candidatos a medicamentos como esses por si próprios, sem interferência da atividade residual do receptor Fc gama murino.”

Os modelos FcResolv NOG eliminam os falsos negativos que ocorrem quando o domínio Fc de um terapêutico com base em anticorpos interage com os FcγRs murinos, bem como os falsos positivos que resultam quando os FcγRs desencadeiam atividade imune murina residual. Eles também eliminam as etapas dispendiosas de desconvolução que normalmente são necessárias para distinguir a verdadeira eficácia do medicamento dos efeitos fora do alvo mediados pelo sistema imunológico do camundongo. Com respostas mais confiáveis, os pesquisadores podem direcionar seus investimentos em descoberta de medicamentos de forma mais estratégica e eficaz.

O portfólio do modelo FcResolv NOG tem como base o CIEA NOG mouse® superimunodeficiente. Atualmente, o portfólio inclui dois modelos:

  • FcResolv NOG, para xenoenxertos de tumores com linhagens celulares ou tumores derivados de pacientes, enxerto de outras células e tecidos humanos normais ou patológicos, e estudos de humanização do sistema imunológico
  • FcResolv hIL-15 NOG, que aceita enxertos de células NK humanas e é adequado para estudos de eficácia em terapêutica com base em anticorpos com um mecanismo de ação de citotoxicidade celular dependente de anticorpos (ADCC)

Para mais informação sobre o portfólio FcResolv NOG, visite www.Taconic.com/fcresolv. Ou ligue para 1-888-TACONIC (888-822-6642) nos EUA, +45 70 23 04 05 na Europa, ou envie email para info@taconic.com.

Sobre a Taconic Biosciences, Inc.

A Taconic Biosciences é uma líder global totalmente licenciada em serviços e modelos geneticamente modificados. Fundada em 1952, a Taconic oferece as melhores soluções/modelos de pesquisas em murinos, para que os clientes possam adquirir, customizar, criar, pré-condicionar, testar e distribuir valiosos modelos de pesquisa em todo o mundo. Especializada em modelos de camundongos e de ratos geneticamente projetados, microbioma, modelos de camundongos imuno-oncologia, e serviços de design e criação de modelos integrados, a Taconic opera laboratórios de serviços e instalações de criação nos EUA e na Europa, mantém relações com distribuidores na Ásia , e tem capacidades de entrega em nível global para oferecer modelos em quase qualquer lugar no mundo.

Contato com a Mídia:

Louise Baskin, Diretora Sênior de Pipeline de Novos Produtos

303-432-2495

Louise.Baskin@taconic.com

GlobeNewswire Distribution ID 8670426

Cameroon Says Cholera Hits Minawao, a Nigerian Refugee Camp

Authorities in Cameroon say they are struggling to contain a cholera outbreak in an overcrowded refugee camp on its northern border with Nigeria. In the past week, three people have died in the Minawao refugee camp and at least 81 have been infected from the bacteria, which spreads through dirty water and food. The camp was designed to hold fewer than 15,000 refugees but currently has more than five times that number.
The camp located on Cameroon’s northern border is home to 76,000 Nigerians who have fled Boko Haram terrorist attacks.
Helen Ngoh, spokesperson for UNHCR Cameroon says the U.N. body needs support to contain the ongoing wave of infections and to prevent future outbreaks in the refugee camp.
“In Minawao specifically UNHCR needs at least 450,000 U.S. dollars to be able to increase portable water supply and also to be able to cover an existing gap of 900 latrines and to be able to improve waste management in the camp as well. All of these needs are extremely urgent at this point,” she said.

UNHCR says it is investigating suspected cases and treating patients free of charge. The refugee agency says it is also finding out if the disease has spread to host communities.
Ngoh said several hundred humanitarian workers have been deployed to the camp and host communities to educate refugees on prevention measures, which she said are basically respecting hygiene rules.
Nigerian refugee Special Bulama is among aid workers raising awareness about the outbreak and teaching civilians good hygiene practices.
Bulama says he has personally spoken about the disease to scores of families in the camp.
“We are telling the refugees to take care of themselves, they must boil water before they take [drink], they must wash their hands with Sabulu [soap], keep their latrines very safe because flies can take this disease to their food or to their water. We are telling them to help us to avoid this problem of cholera,” he said.
Cameroon’s Ministry of Public Health has confirmed the outbreak. Government health officials say at least 22 people have died of cholera in several villages on Cameroon’s northern border with Nigeria and Chad. Humanitarian workers and health officials say many more people may be infected or are feared dead in difficult to access villages within the past two weeks.
The U.N. reports that up to October, more than 1,000 cases of cholera were reported in Nigeria.
Cameroon says hospitals in border localities are overwhelmed.
Officials in Cameroon say they are engaged in discussions with Nigeria and Chad to jointly combat cholera, a bacterial infection that causes severe diarrhea and dehydration, usually spread through contaminated water. It can be fatal if not treated.

Source: Voice of America

WHO Says a Polio-Free World Within Grasp

In marking World Polio Day, advocates for a polio-free world are urging nations to commit to a new five-year strategy to eradicate this crippling disease and consign it to the trash bin of history.

An estimated 350,000 children were paralyzed by polio when the World Health Organization launched its Global Polio Eradication Initiative in 1988. In the world today, polio is endemic only in Pakistan, and Afghanistan. So far this year, 29 cases have been recorded, putting the possibility of a polio-free world within reach.

The WHO notes the final stretch is the most difficult and cautions nations against letting down their guard too soon. WHO Director-General Tedros Adhanom Ghebreyesus says the 29 recorded cases include a small number in southeast Africa linked to a strain originating in Pakistan.

“While it does not affect the WHO African region’s wild polio free certification, it shows us that as long as polio continues to circulate anywhere, it is a threat to children everywhere. Despite this news, we have a unique window of opportunity right now to end polio for good.”

The WHO warns polio also can spread within communities through circulating vaccine-derived polioviruses. These variants, it notes, can emerge in places where not enough people have been immunized against this crippling disease. It reports these variants continue to spread across parts of Africa, Asia, and Europe and new outbreaks have been detected in Britain, Israel and the United States in recent months.

UNICEF Executive Director Catherine Russell says the new polio eradication strategy is designed to take the world to the finish line. She says the strategy includes tactics to protect children from variant outbreaks and stop their spread to other countries.

“We are also working with governments to speed up our response to these outbreaks, acting immediately to ensure that they do not harm more children,” Russel said. “And we continue working to integrate polio activities with other immunization and health programs so we can reach high-risk children who have never received vaccines before. The new strategy will help us end all forms of polio. It will also help prepare countries to respond to future health threats.”

If this goal is reached, polio will become only the second disease after smallpox to have been wiped off the face of the Earth. U.N. health agencies say it will cost $4.8 billion to achieve this historic milestone.
The economic returns, they say, will be significant. They estimate eradicating polio would result in savings of more than $33 billion.

Source: Voice of America

Bill & Melinda Gates Foundation Announces Additional Support to Promote Locally Led R&D; Calls for Proposals 

BRUSSELS, Oct. 24, 2022 /PRNewswire/ — The Bill & Melinda Gates Foundation today announced a series of initiatives and a call for proposals to advance locally-led innovation that supports work by scientists and researchers in developing economies. The announcement was made at the Grand Challenges Annual Meeting earlier today.

This year’s meeting focuses on lessons learned from the COVID-19 pandemic, which highlighted the need for high-impact R&D platforms, partnerships, and policies that effectively bridge the gap between innovation and equitable access. The meeting brings together researchers from around the world to share work, learn about cutting-edge advances in the health care field, and collaborate with other investigators.

“Health equity shouldn’t just be a statement of why we do this work. It should guide how we do it,” said Kedest Tesfagiorgis, deputy director of Global Partnerships & Grand Challenges at the Bill & Melinda Gates Foundation. “When we support locally led innovation, we maximize impact by bringing different kinds of knowledge and perspectives to the fore.”

As part of the Grand Challenges Global Call to Action, a 10-year initiative announced at last year’s meeting to help ensure scientists and institutions in low- and middle-income countries (LMICs) play a central role in shaping the global R&D agenda, the foundation announced two new Grand Challenges initiatives:

  • Pathogen Genomic Surveillance and Immunology in Asia : This is an invitation for proposals from investigators in South and Southeast Asia to design and pilot a genomic surveillance program or develop capacity for immunology and immune sequencing of SARS-CoV-2 to inform epidemic response. Up to $300,000 per year for up to two years will be available for each project, with potential additional funding for projects that include a focus on monoclonal antibody discovery.
  • Building Data Modeling Capacity for Gender Equality : This is an invitation for proposals from investigators in low- and middle-income countries for projects aimed at addressing disparities and gaps affecting women and girls in health. This initiative is focused on innovative approaches to modeling that advance gender equality. Each project will receive up to $500,000 over one to three years.

“Societies measure what they value, and for most of history, society hasn’t valued women. This means we’re trying to tackle global health and development challenges with missing information,” said Anita Zaidi, president of the Gender Equality division at the Bill & Melinda Gates Foundation. “It is long past time to put women and girls at the center of the data modeling that guides our solutions.”

In partnership with the Chan Zuckerberg Initiative (CZI), the foundation will also provide grants to researchers investigating and detecting emerging pathogens in LMICs. Researchers will receive up to $200,000 each for up to two years, as well as operational support and technical training from the ChanZuckerberg Biohub (CZ Biohub). This funding commitment builds on a 2018 partnership between the foundation, CZI, and the CZ Biohub that is focused on building metagenomics capacity in LMICs through a Global Grand Challenges initiative.

The 2022 Grand Challenges Annual Meeting in Brussels is hosted by Global Grand Challenges and the European Commission, and co-sponsored by Grand Challenges Canada, USAID, Wellcome, and the Bill & Melinda Gates Foundation.

The two-day event features dozens of leaders from across the global health innovation landscape, as well as Gates Foundation leadership, including Bill Gates (co-chair and trustee); Anita Zaidi; and Trevor Mundel (president, Global Health Division). The plenary sessions will be posted shortly after the meeting at grandchallenges.org/annualmeeting.

About Grand Challenges

The Bill & Melinda Gates Foundation recognizes that solving the most pressing challenges in global health and development requires more of the world’s brightest minds working on them. The Grand Challenges family of initiatives seeks to engage innovators from around the world to solve these challenges. Grand Challenges initiatives are united by their focus on fostering innovation, directing research to where it will have the most impact, and serving those most in need. To learn more, visit grandchallenges.org.

About the Bill & Melinda Gates Foundation

Guided by the belief that every life has equal value, the Bill & Melinda Gates Foundation works to help all people lead healthy, productive lives. In developing countries, it focuses on improving people’s health and giving them the chance to lift themselves out of hunger and extreme poverty. In the United States, it seeks to ensure that all people—especially those with the fewest resources—have access to the opportunities they need to succeed in school and life. Based in Seattle, Washington, the foundation is led by CEO Mark Suzman, under the direction of Co-chairs Bill Gates and Melinda French Gates and the board of trustees.

Media contact: media@gatesfoundation.org

Climate Protesters Throw Mashed Potatoes at Monet Painting

Climate protesters threw mashed potatoes at a Claude Monet painting in a German museum to protest fossil fuel extraction Sunday but caused no damage to the artwork.
Two activists from the group Last Generation, which has called on the German government to take drastic action to protect the climate and stop using fossil fuels, approached Monet’s “Les Meules” at Potsdam’s Barberini Museum and threw a thick substance over the painting and its gold frame.
The group later confirmed via a post on Twitter that the mixture was mashed potatoes. The two activists, both wearing orange high-visibility vests, also glued themselves to the wall below the painting.
“If it takes a painting – with #MashedPotatoes or #TomatoSoup thrown at it – to make society remember that the fossil fuel course is killing us all: Then we’ll give you #MashedPotatoes on a painting!” the group wrote on Twitter, along with a video of the incident.
In total, four people were involved in the incident, according to German news agency dpa.

The Barberini Museum said later Sunday that because the painting was enclosed in glass, the mashed potatoes didn’t cause any damage. The painting, part of Monet’s “Haystacks” series, is expected to be back on display Wednesday.
“While I understand the activists’ urgent concern in the face of the climate catastrophe, I am shocked by the means with which they are trying to lend weight to their demands,” museum director Ortrud Westheider said in a statement.
Police told dpa they had responded to the incident, but further information about arrests or charges was not immediately available.
The Monet painting is the latest artwork in a museum to be targeted by climate activists to draw attention to global warming.
The British group Just Stop Oil threw tomato soup at Vincent van Gogh’s “Sunflowers” in London’s National Gallery earlier this month.
Just Stop Oil activists also glued themselves to the frame of an early copy of Leonardo da Vinci’s “The Last Supper” at London’s Royal Academy of Arts, and to John Constable’s “The Hay Wain” in the National Gallery.

Source: Voice of America

Uganda Says Two More Ebola Cases Confirmed in Kampala Hospital

Two more people in an isolation unit of Uganda’s main hospital have tested positive for Ebola, bringing total cases recorded in the facility to five, the health minister said on Sunday.
The five confirmed cases in Kampala are the first known transmission of the virus in the city, coming days after the information ministry said the country’s Ebola outbreak was coming under control and was expected to be over by the end of the year.

Health Minister Jane Ruth Aceng said on Saturday that three patients among 60 people in isolation at Kampala’s Mulago Hospital tested positive for the disease a day earlier.
She had said the three infected people had been in contact with a patient from Kassanda district in central Uganda who had died in Mulago.
“Two more contacts to the Kassanda case, who are quarantined in Mulago Isolation facility, tested positive for Ebola yesterday…” Aceng said on Twitter.
She added the two had been transferred to a treatment unit at a hospital in Entebbe, 41 km (25 miles) away.

The government has introduced a three-week lockdown around the Mubende and Kassanda districts in central Uganda, the epicenter of the outbreak of the Sudan variant of the Ebola virus.
A government statement on Friday said the outbreak had by then infected 65 people and killed 27. It was not clear if the numbers included the three first new Kampala cases.
The government said last week two other cases of Ebola confirmed in Kampala had come from Mubende and were regarded as originating there, not the capital.

Source: Voice of America

‘Change Has Come’: Mississippi Unveils Emmett Till Statue

Hundreds of people applauded — and some wiped away tears — as a Mississippi community unveiled a larger-than-life statue of Emmett Till on Friday, not far from where white men kidnapped and killed the Black teenager over accusations he had flirted with a white woman in a country store.
“Change has come, and it will continue to happen,” Madison Harper, a senior at Leflore County High School, told a racially diverse audience at the statue’s dedication.
“Decades ago, our parents and grandparents could not envision that a moment like today would transpire.”
The 1955 lynching became a catalyst for the civil rights movement. Till’s mother, Mamie Till-Mobley, insisted on an open-casket funeral in Chicago so the world could see the horrors inflicted on her 14-year-old son. Jet magazine published photos of his mutilated body, which was pulled from the Tallahatchie River in Mississippi.
The 2.7-meter-tall bronze statue in Greenwood’s Rail Spike Park is a jaunty depiction of the living Till in slacks, dress shirt and tie with one hand on the brim of a hat.
The rhythm and blues song, Wake Up, Everybody played as workers pulled a tarp off the figure. Dozens of people surged forward, shooting photos and video on cellphones.
Anna-Maria Webster of Rochester, New York, had tears running down her face.
“It’s beautiful to be here,” said Webster, attending the ceremony on a sunny afternoon during a visit with Mississippi relatives. Speaking of Till’s mother she said: “Just to imagine the torment she went through — all over a lie.”
Mississippi has the highest percentage of Black residents of any state, now about 38%.
Democratic U.S. Rep. Bennie Thompson, whose district encompasses the Delta, noted that Mississippi had no Black elected officials when Till was killed. He said Till’s death helped spur change.
“But you, know, change has a way of becoming slower and slower,” said Thompson, the only Black member of Mississippi’s current congressional delegation. “What we have to do in dedicating this monument to Emmett Till is recommit ourselves to the spirit of making a difference in our community.”
The statue is a short drive from an elaborate Confederate monument outside the Leflore County Courthouse and about 16 kilometers from the crumbling remains of the store, Bryant’s Grocery & Meat Market, in Money.
The statue’s unveiling coincided with the release this month of Till, a movie exploring Till-Mobley’s private trauma over her son’s death and her transformation into a civil rights activist.
The Rev. Wheeler Parker Jr., the last living witness to his cousin’s kidnapping, wasn’t able to travel from Illinois for Friday’s dedication. But he told The Associated Press on Wednesday: “We just thank God someone is keeping his name out there.”
He said some wrongly thought Till got what he deserved for breaking the taboo of flirting with a white woman, adding many people didn’t want to talk about the case for decades.
“Now there’s interest in it, and that’s a godsend,” Parker said. “You know what his mother said: ‘I hope he didn’t die in vain.’”
Greenwood and Leflore County are both more than 70% Black, and officials have worked for years to bring the Till statue to reality. Democratic state Sen. David Jordan of Greenwood secured $150,000 in state funding and a Utah artist, Matt Glenn, was commissioned to create the statue.
Jordan said he hopes it will draw tourists to learn more about the area’s history. “Hopefully, it will bring all of us together,” he said.
Till and Parker had traveled from Chicago to spend the summer of 1955 with relatives in the deeply segregated Mississippi Delta. On Aug. 24, the two teens took a short trip with other young people to the store in Money. Parker said he heard Till whistle at shopkeeper Carolyn Bryant.
Four days later, Till was abducted in the middle of the night from his uncle’s home. The kidnappers tortured and shot him, weighted his body down with a cotton gin fan and dumped him into the river.
Jordan, who is Black, was a college student in 1955 when he drove to the Tallahatchie County Courthouse in Sumner to watch the murder trial of two white men charged with killing Till — Carolyn’s husband Roy Bryant and his half brother, J.W. Milam.
An all-white, all-male jury acquitted the two men, who later confessed to Look magazine that they killed Till.
Nobody has ever been convicted in the lynching. The U.S. Justice Department has opened multiple investigations starting in 2004 after receiving inquiries about whether charges could be brought against anyone still living.
In 2007, a Mississippi prosecutor presented evidence to a grand jury of Black and white Leflore County residents after investigators spent three years reexamining the killing. The grand jury declined to issue indictments.
The Justice Department reopened an investigation in 2018 after a 2017 book quoted Carolyn Bryant — now remarried and named Carolyn Bryant Donham — saying she lied when she claimed Till grabbed her, whistled and made sexual advances. Relatives have publicly denied Donham, who is in her 80s, recanted her allegations. The department closed that investigation in late 2021 without bringing charges.
This year, a group searching the Leflore County Courthouse basement found an unserved 1955 arrest warrant for “Mrs. Roy Bryant.” In August, another Mississippi grand jury found insufficient evidence to indict Donham, causing consternation for Till relatives and activists.
Although Mississippi has dozens of Confederate monuments, some have been moved in recent years, including one relocated in 2020 from the University of Mississippi campus to a cemetery where Confederate soldiers are buried.
The state has a few monuments to Black historical figures, including one honoring civil rights activist Fannie Lou Hamer in Ruleville.
A historical marker outside Bryant’s Grocery has been knocked down and vandalized.
Another marker near where Till’s body was pulled from the Tallahatchie River has been vandalized and shot. The Till statue in Greenwood will be watched by security cameras.
Jordan won applause when he said Friday: “If some idiot tears it down, we’re going to put it right back up.”

Source: Voice of America

Boeing Crashes: Passengers’ Families Deemed Crime Victims

A federal judge ruled Friday that relatives of people killed in the crashes of two Boeing 737 Max planes are crime victims under federal law and should have been told about private negotiations over a settlement that spared Boeing from criminal prosecution.
The full impact of the ruling is not yet clear, however. The judge said the next step is to decide what remedies the families should get for not being told of the talks with Boeing.
Some relatives are pushing to scrap the government’s January 2021 settlement with Boeing, and they have expressed anger that no one in the company has been held criminally responsible.
Boeing Co., which is based in Arlington, Virginia, did not immediately respond to a request for comment.
Boeing, which misled safety regulators who approved the Max, agreed to pay $2.5 billion including a $243.6 million fine. The Justice Department agreed not to prosecute the company for conspiracy to defraud the government.
The Justice Department, in explaining why it didn’t tell families about the negotiations, argued that the relatives are not crime victims. However, U.S. District Judge Reed O’Connor in Fort Worth, Texas, said the crashes were a foreseeable consequence of Boeing’s conspiracy, making the relatives representatives of crime victims.
“In sum, but for Boeing’s criminal conspiracy to defraud the FAA, 346 people would not have lost their lives in the crashes,” he wrote.
Naoise Connolly Ryan, whose husband died in the second Max crash, in Ethiopia, said Boeing is responsible for his death.
“Families like mine are the true victims of Boeing’s criminal misconduct, and our views should have been considered before the government gave them a sweetheart deal,” she said in a statement issued by a lawyer for the families.
The first Max crashed Indonesia in October 2018, killing 189, and another crashed five months later in Ethiopia, killing 157. All Max jets were grounded worldwide for nearly two years. They were cleared to fly again after Boeing overhauled an automated flight-control system that activated erroneously in both crashes.

Source: Voice of America