Geneva: A new Ebola vaccine trial targeting the Bundibugyo species of the virus has commenced in the United Kingdom, with another scheduled to start in Canada, as the Democratic Republic of the Congo (DRC) grapples with the largest outbreak on record. This development was announced by the World Health Organization (WHO) on Tuesday, highlighting the urgent global efforts to develop the first vaccine for this specific Ebola species amid rising cases and deaths.According to United Nations, the outbreak in the DRC has seen 3,748 cases, including 1,657 deaths and 708 recoveries as of August 1. While vaccines for other Ebola strains exist, this trial marks the first attempt to address the Bundibugyo species specifically. Clinical trials have been initiated more swiftly compared to past outbreaks due to pre-written protocols, as noted by Vasee Moorthy, acting lead of WHO's R and D Blueprint, which coordinates global research efforts in response to outbreaks.Despite these advancements, Dr. Moorthy emphasized that there are currently no proven safe and effective treatments or vaccines for the Bundibugyo species. The ongoing trials may take several months before yielding conclusive results.In the UK, the vaccine trial entered phase one on July 24, and a similar trial is expected to commence in Canada. Both trials are initially being conducted on animals, such as ferrets and monkeys, with WHO analyzing the results before proceeding to the next phase. Additionally, new data from animal studies on the licensed vaccine Ervebo, which targets a different Ebola strain, has emerged, with WHO's technical advisory group set to publish recommendations soon.In Ituri province, a clinical trial for a potential post-exposure prophylaxis is underway, led by the DRC's National Institute for Biomedical Research in collaboration with international partners. This trial aims to evaluate if an oral medicine administered for 10 days can prevent disease onset in confirmed high-risk contacts. Three testing sites have already been establish ed in the province, with plans for a fourth to open soon, facilitating patient enrollment and monitoring.The United Nations is actively supporting various Ebola response initiatives. The UNHCR is involved in screening, infection prevention, and risk communication, while UNICEF operates nurseries for children from affected families. Additionally, a mobile lab at the DRC-Uganda border, supported by WHO and the World Food Programme, provides rapid Ebola diagnostics. The MONUSCO peacekeeping mission is enhancing security around medical facilities, and the UN's Global Emergency Fund, CERF, is releasing up to $60 million for response efforts.
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